Below is an article that I presented for my Final Site Visit for Pediatrics on a patient with Lennox-Gaustaut syndrome.
Article Summary
Lennox-Gastaut Syndrome is a lifelong condition associated with the onset of severe seizures in childhood, treatment-resistant epilepsy, intellectual disability, cognitive impairment, and behavioral abnormalities. For these patients, regardless of the medication regimen they are on, most of their life is dependent on a caretaker. Anti-Seizure medications such as Valproate and lamotrigine may reduce the frequency of seizures.
The article I presented suggests that Cannabidiol at a dose of 10 or 20mg per kilogram per day compared to a conventional anti-epileptic regimen resulted in a greater reduction in drop (atonic) seizures. Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy.
In conclusion, it is possible that cannabidiol may lead to a reduction in atonic seizures. However, the patient will still have many seizures, and intellectual, and behavioral disabilities, and will likely be dependent on a caregiver for the rest of their life.
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